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Research Article

Influence of MWCNTS on mechanical and in vitro biocompatibility properties of PMMA bone cement for orthopedic application

T V Vineeth Kumar1N Shanmugapriya1Arun S2Madeva Nagaral3

1Department of Mechanical Engineering, Siddaganga Institute of Technology (Autonomous Institution Affiliated to Visvesvaraya Technological University, Belagavi), Tumakuru 572 103, Karnataka, India

2Advanced Composites Division, CSIR - National Aerospace Laboratories, Bengaluru 560 017, Karnataka, India

3Aircraft Research and Design Centre, Hindustan Aeronautics Limited, Bengaluru 56003, Karnataka, India



Bone Cement;

Carbon Nanotubes;                            

Compressive Strength;




Polymethyl methacrylate (PMMA) serves as sealing material in securing the implant and distributing the load between the implant and bone. Fast polymerization and speedy patient recovery after surgery are the main benefits of using PMMA bone cement. Considering PMMA for orthopedic applications, the mechanical properties and biocompatibility studies are important. In this study, Simplex P bone cement is reinforced with carboxyl functionalized multiwall carbon nanotubes (MWCNTs-COOH) to evaluate compressive strength, Shore D hardness, and in vitro biocompatibility properties. MWCNTs are added to the PMMA powder in different amounts using a geometric dilution technique. The PMMA/MWCNT nanocomposite is prepared with MWCNTs varying from 0.1 wt. % to 0.7 wt. %. The compressive strength and Shore D hardness values increased to a maximum of 69.21% and 4.84%, respectively for 0.3 wt. % loading. The in vitro cytotoxicity studies on MG-63 cells show a percentage cell viability of 81.37 % for 0.3 wt. % and 83.25 % for 0.7 wt. % MWCNTs loading. Hemolysis studies on human B+ve blood exhibited a low hemolytic potential of 15.12% for 0.3 wt. % and 16.38% for 0.7 wt. % MWCNTs loading on human RBCs. It is concluded that the prepared PMMA/MWCNT nanocomposites are found to have enhanced mechanical properties compared to Simplex P bone cement.

© 2023 MIM Research Group. All rights reserved.


01/01/2024 Best Paper Award: The winners of 2023 Best Paper Award of Research on Engineering Structures and Materials (RESM) are announced. More information can be found at Author Awards section.

01/01/2024 Most Cited Paper Award: The winners of 2023 Most Cited Paper Award of Research on Engineering Structures and Materials (RESM) are announced. More information can be found at Author Awards section.

01/01/2024 Reviewer Awards: The winners of 2023 reviewer awards of Research on Engineering Structures and Materials (RESM) are announced. More information can be found at Reviewer Awards section.

8/12/2023 Special Issue: Embark on a journey of innovation with the journal of Research on Engineering Structures and Materials as we unveil a compelling opportunity for contributors in our upcoming special issue, "Design, Analysis, and Manufacturing of Composite Vehicle Structures." Led by distinguished Guest Editors Liubov Gavva and Oleg Mitrofanov from Moscow Aviation Institute. For more info see the link.

21/10/2023 Journal Submission System Upgrade Completed: We're delighted to announce that our Journal Submission and Tracking System has undergone a significant upgrade, aimed at enhancing user experience. 

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2023 Reviewer Awards:

Please, visit Reviewer Awards section for the winners of the 2022 RESM reviewer awards.

2023 Best Paper Award:

The paper authored by Ferzan Fidan, Naim Aslan, Mümin Mehmet Koç entitled as “Morpho-structural and compressive mechanical properties of graphene oxide reinforced hydroxyapatite scaffolds for bone tissue applications” is awarded.

2023 Most Cited Paper Award:

The paper authored by Ercan Işık, Ehsan Harirchian, Hüseyin Bilgin, Kirti Jadhav entitled as “The effect of material strength and discontinuity in RC structures according to different site-specific design spectra" is awarded.


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