This study explores the partial replacement of cement with waste glass powder (WGP) in M25 and M30 grade concrete, ranging from 0% to 20% in 2.5% increments. The mechanical properties assessed include compressive, flexural, and split tensile strengths, as well as predictive modeling using Boost and Random Forest. The optimum performance was observed at 10% WGP replacement, where compressive strength reached 30 MPa for M25 and 35 MPa for M30 after 28 days. Strength declined beyond this point due to cement dilution and possible alkali-silica reaction effects. Flexural and split tensile strengths followed a similar trend, with maximum values recorded at 20% replacement. Slump values dropped from 75 mm to 55 mm for M25 and 53 mm for M30, mainly due to the angular shape and non-absorbent nature of WGP, which reduces workability. A small density reduction of about 2.5% was also noted. Linear regression showed strong correlations between curing time and strength, with R² values of 0.9631 (3 days), 0.8352 (7 days), and 0.8808 (28 days). Negative R² values indicate the XGBoost performed worse than predicting the mean. This behavior was mostly observed for early-age data and is likely due to limited variability and sample size. It also highlighted that Random Forest consistently outperformed XGBoost, especially for 28-day strengths, with positive and moderate-to-high R² scores.