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Research Article

Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study

Güliz Akyüz1, Aykut Elmas1, Müberra Andaç1,2, Ömer Andaç1,2

1Department of Nanoscience and Nanotechnology, Ondokuz Mayıs University, Samsun, Turkey 2Department of Chemistry, Ondokuz Mayıs University, Samsun, Turkey

Keywords

Abstract



Long term release; 

Nano sized Mg@BTC; 

Drug carrier; 

Model fit tests; 

Slow release


Metal Organic Frameworks (MOFs) have found wide applications as a drug carrier in nanotherapeutics because of adjustable pore-sizes, controllable structural properties, large surface area and high pore volume. In this work, nanosized Mg@BTC is synthesized by electrochemical method and used as a new drug carrier for ibuprofen. The ibuprofen (IB) is loaded to the Mg@BTC 1:1 ratio with the amount of %99.8. The release of ibuprofen from nanocarrier has been observed experimentally for long term. After 100.5 hours, the release ratio yields 36 %. The ibuprofen has been tested at 40 ± 0.5 °C. System showed a rapid release after 100 hours, the release ratio yields 72.29 %. The release profile of IB loaded Mg@BTC is tested by using model depended mathematical models to get observation and prediction of the release. Zero Order Model, First Order Model, Higuchi Model, Peppas Model and Hixon Model functions are fitted to the release profiles. Watson’s U Squared Method is used to test the fit strength of the models. Observation from the release profiles, it is seemed Peppas Model yields the best results. Also, thermodynamic analysis has been studied.

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LATEST News

02/11/2020 Indexed by SCOPUS: We are informed that our journal is accepted to be included in the SCOPUS Index. See mews for more info.


20/08/2020 Collaboration for IMSTEC 2020: Editorial Board of our journal and Organizing Committee of the 5. International Conference on Material Science and Technology (IMSTEC 2020) have agreed to collaborate. Extended versions of the selected papers from the conference will be published in our journal. For more see Events.


25/12/2019 Most Cited Paper Award: The paper authored by Manoj Sahni and Sanjeev Sharma entitled as “Elastic-plastic deformation of a thin rotating solid disk of exponentially varying density" is awarded the 2019 Most Cited Paper Award of Research on Engineering Structures and Materials (RESM).


25/12/2019 Best Paper Award: The paper authored by Marcelo Mesquita do Amaral, Matheus Wanglon Ferreira and Mauro de Vasconcellos Real entitled as “A simplified method for analysis of reinforced concrete beams exposed to fire situation” is awarded the 2019 Best Paper Award of Research on Engineering Structures and Materials (RESM).


13/11/2019 Data articles as a new type of submision: Editorial Board of our journal have decided to accept a new type of submission: data articles. The focus of these papers is only on data and how it is collected but not on its interpretation and drawn conclusions. For more see News section.


(More details of the news may be given in the News section)


For more see News...

LATEST AWARDS


2019 Most Cited Paper Award:

The paper authored by Manoj Sahni and Sanjeev Sharma entitled as “Elastic-plastic deformation of a thin rotating solid disk of exponentially varying density" is awarded the


2019 Best Paper Award:

The paper authored by Marcelo Mesquita do Amaral, Matheus Wanglon Ferreira and Mauro de Vasconcellos Real entitled as “A simplified method for analysis of reinforced concrete beams exposed to fire situation” is awarded the 


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Last Update:

19.11.2020

(dd.mm.yyyy)